Analysis of pharmaceutical creams: a useful approach based on solid-phase extraction (SPE) and UV spectrophotometry.

@article{Bonazzi1995AnalysisOP,
  title={Analysis of pharmaceutical creams: a useful approach based on solid-phase extraction (SPE) and UV spectrophotometry.},
  author={Daniela Bonazzi and Vincenza Andrisano and Rita Gatti and Vanni Cavrini},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1995},
  volume={13 11},
  pages={
          1321-9
        }
}
Solid-phase extraction (SPE) using C-18, diol and ion-exchange sorbents followed by UV spectrophotometric (conventional and derivative mode) assay was applied to the analysis of basic, acidic and neutral drugs commercially available in creams. A representative set of drugs (promethazine, chlorhexidine, benzydamine, ketoprofen, ibuprofen, fentiazac, piroxicam, fluorouracil, crotamiton and hydrocortisone acetate) was selected, and for each drug the appropriate SPE conditions (adsorption, washing… CONTINUE READING
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