Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model

@article{Gabrielsson1986AnalysisOP,
  title={Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model},
  author={Johan Gabrielsson and Per Johansson and U. G. Bondesson and Mats Karlsson and Lennart K. Paalzow},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1986},
  volume={14},
  pages={381-395}
}
The disposition of pethidine (meperidine) in the pregnant rat is described by means of a physiological flow model. The model includes arterial and venous blood, brain, fat, fetal, hepatic, intestinal, muscular, pulmonar, and renal tissues. The concentration-time profiles of pethidine calculated by the model are consistent with experimental data, except for the brain and renal tissues, where the model predicts initially higher concentrations. Simulations are carried out to further explore the… CONTINUE READING