Analysis of peptides and proteins in their binding to GroEL.

  title={Analysis of peptides and proteins in their binding to GroEL.},
  author={Yali Li and Zhida Zheng and Andrew S Ramsey and Lingling Chen},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  volume={16 12},
The GroEL-GroES is an essential molecular chaperon system that assists protein folding in cell. Binding of various substrate proteins to GroEL is one of the key aspects in GroEL-assisted protein folding. Small peptides may mimic segments of the substrate proteins in contact with GroEL and allow detailed structural analysis of the interactions. A model peptide SBP has been shown to bind to a region in GroEL that is important for binding of substrate proteins. Here, we investigated whether the… CONTINUE READING


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