Analysis of peptaibol sequence composition: implications for in vivo synthesis and channel formation

@article{Whitmore2003AnalysisOP,
  title={Analysis of peptaibol sequence composition: implications for in vivo synthesis and channel formation},
  author={Lee Whitmore and B. A. Wallace},
  journal={European Biophysics Journal},
  year={2003},
  volume={33},
  pages={233-237}
}
The sequence entries in the Peptaibol Database were analysed to provide information on compositional features of this unusual family of peptides. The non-standard amino acid α-aminoisobutyric acid represents almost 40% of the residues in all the known sequences. Glutamine is the only significant polar residue in peptaibols, and the position and number of these residues appear to be related to their functional properties as ion channels. Aromatic residues are clustered at the termini, which may… Expand
CHAPTER 14 – Peptaibols
TLDR
The peptaibols are a large family of homologous peptides isolated from soil fungi, characterized by having a high content of alpha-aminoisobutyric acid (Aib) residues and generally have both N-terminal modifications in the form of amino alcohol groups rather than amino acids. Expand
Helical kink and channel behaviour: a comparative study with the peptaibols alamethicin, trichotoxin and antiamoebin
  • H. Duclohier
  • Chemistry, Medicine
  • European Biophysics Journal
  • 2003
TLDR
This short review compares the monomeric structures of three selected peptaibols that widely differ with regards to their near-central kink angles and dipolar moment orientations and shows these structural features to be correlated to the different patterns of channel activity, both at the macroscopic and single-channel levels of investigation. Expand
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The Peptaibol Database is a sequence and structure resource for the unusual class of peptides known as peptaibols. These peptides exhibit antibiotic and membrane channel-forming activities. TheExpand
Biosynthesis and Molecular Genetics of Peptaibiotics—Fungal Peptides Containing Alpha, Alpha-Dialkyl Amino Acids
Peptaibiotics are peptide secondary metabolites rich in alpha, alpha-dialkyl amino acids from filamentous fungi, especially the members of the genus Trichoderma (anamorph of Hypocrea). In contrast toExpand
Peptaibolin analogues by incorporation of α,α-dialkylglycines: synthesis and study of their membrane permeating ability
Abstract Analogues of Peptaibolin, a peptaibol with antibiotic activity, incorporating α,α-dialkylglycines (Deg, Dpg, and Ac6c) at selected positions were synthesised by MW-SPPS and fullyExpand
Systematic Design and Validation of Ion Channel Stabilization of Amphipathic α-Helical Peptides Incorporating Tryptophan Residues
TLDR
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TLDR
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Peptaibiomics: an advanced, rapid and selective analysis of peptaibiotics/peptaibols by SPE/LC-ES-MS
TLDR
A specific and rapid screening method applicable directly onto filamentous fungi cultured in a single Petri dish and the judgement is possible whether or not structures are novel, already known or related to known structures. Expand
Facts and Challenges in the Understanding of the Biosynthesis of Peptaibols by Trichoderma
TLDR
This review article used the recent knowledge on biosynthesis and production of these components to speculate on some of the unknown points and highlights areas where further research is most urgently needed. Expand
Cyclodextrin-scaffolded alamethicin with remarkably efficient membrane permeabilizing properties and membrane current conductance.
TLDR
Alamethicin belongs to a class of peptides called peptaibols and represents one of these antimicrobial peptides, and the α-helices of the templated multimers were demonstrated to insert into lipid bilayers forming highly efficient and remarkably stable ion-channels. Expand
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TLDR
Crystal structures determined for a number of peptaibols from the various SFs provide the bases both for modelling of the channel structures and for modelling structures of other members of the same SFs. Expand
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TLDR
These studies suggest that peptaibols form proline-kinked α-helices, and that there may be “hinge-bending” movement of the helix in the region of the central proline residue. Expand
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TLDR
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