Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways.

@article{Gu2011AnalysisOP,
  title={Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways.},
  author={Yunyan Gu and Wenyuan Zhao and Jiguang Xia and Yuannv Zhang and Ruihong Wu and Chenguang Wang and Zheng Guo},
  journal={Human mutation},
  year={2011},
  volume={32 9},
  pages={
          1028-35
        }
}
The biological interpretation of the complexity of cancer somatic mutation profiles is a major challenge in current cancer research. It has been suggested that mutations in multiple genes that participate in different pathways are collaborative in conferring growth advantage to tumor cells. Here, we propose a powerful pathway-based approach to study the functional collaboration of gene mutations in carcinogenesis. We successfully identify many pairs of significantly comutated pathways for a… CONTINUE READING
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