Analysis of pancreatic endocrine development in GDF11‐deficient mice

@article{Dichmann2006AnalysisOP,
  title={Analysis of pancreatic endocrine development in GDF11‐deficient mice},
  author={Darwin S. Dichmann and Hani Yassin and Palle Serup},
  journal={Developmental Dynamics},
  year={2006},
  volume={235}
}
Here, we examine the role of GDF11 in pancreatic development. Using in situ hybridization and reverse transcriptase‐polymerase chain reaction analyses, we show that Gdf11 transcripts are expressed in embryonic pancreas epithelium before the secondary transition but decrease rapidly afterward. To determine the function of GDF11 during pancreas development, we analyzed Gdf11−/− mouse embryos. In such embryos, pancreas size is twofold reduced at embryonic day (E) 18 compared with wild‐type… 
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