Analysis of p53 binding to DNA by fluorescence imaging microscopy.

Abstract

Transcription factors play a central role in cell biology through binding to target DNA elements and regulating gene expression. In this study, we used the p53 tumour suppressor as a model transcription factor to develop an imaging based assay to measure DNA binding. The assay utilizes fluorescence imaging microscopy to detect labelled p53 bound to DNA… (More)
DOI: 10.1016/j.micron.2012.03.024

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