Analysis of p53 Gene Polymorphisms and Protein Over-expression in Patients with Breast Cancer

  title={Analysis of p53 Gene Polymorphisms and Protein Over-expression in Patients with Breast Cancer},
  author={Mustafa Akkiprik and Ozgur Sonmez and Bahadir M. Gũllũoğlu and Hale Başak Çağlar and H. Bet{\"u}l Kaya and Pakize Demirkalem and Ufuk M Abacioglu and Meric Sengoz and Aydin Sav and Ayşe Nurdan Ozer},
  journal={Pathology & Oncology Research},
p53 polymorphic variants play an important role in the determination of tumor phenotype and characteristics in breast cancer. In this study, we examined three common polymorphisms in p53 gene and their haplotype combinations to assess their potential association with inherited predisposition to breast cancer development, in relations with the protein over-expression and patients’ demographic data. A total of 99 patients with breast cancer and 107 age-matched healthy controls were included in… CONTINUE READING

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