Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.

@article{Dyson1993AnalysisOP,
  title={Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.},
  author={Nicholas John Dyson and Marlene S Dembski and Ali Fattaey and Chidi Ngwu and MarilynP. Ewen and Kristian Helin},
  journal={Journal of virology},
  year={1993},
  volume={67 12},
  pages={
          7641-7
        }
}
The binding of viral oncogenes to cellular proteins is thought to modulate the activities of these cellular targets. The p107 protein is targeted by many viral proteins, including adenovirus E1A, simian virus 40 large T antigen, and human papillomavirus type 16 E7 protein. A panel of monoclonal antibodies against p107 was raised and used to identify cellular proteins that interact with the p107 protein in vivo. p107-associated proteins included cyclin A, cyclin E, and cdk2. In addition, p107… CONTINUE READING

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