Analysis of oxygen consumption and mitochondrial permeability with age in mice.

@article{Goodell1998AnalysisOO,
  title={Analysis of oxygen consumption and mitochondrial permeability with age in mice.},
  author={Sarah Goodell and Gino A. Cortopassi},
  journal={Mechanisms of ageing and development},
  year={1998},
  volume={101 3},
  pages={245-56}
}
Biochemical and physiological parameters have been investigated in purified liver mitochondria from C57BL/6J mice of relatively young and old age, 1 month vs. 36 months. Under identical purification conditions, mitochondria from old animals consumed significantly less O2 under state 3 conditions (i.e. with saturating ADP stimulation), consistent with a lower activity of the electron transport chain. In the absence of ADP (i.e. state 4 conditions), old mitochondria consumed significantly more O2… CONTINUE READING

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