Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice.

@article{Depianto2003AnalysisON,
  title={Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice.},
  author={Daryle Depianto and Tom N Blankenship and John F. Hess and Paul G. Fitzgerald},
  journal={Molecular vision},
  year={2003},
  volume={9},
  pages={288-94}
}
PURPOSE To examine the role of the c-Maf transcription factor in the regulation of non-crystallin lens fiber cell specific gene expression. METHODS Expression of lens fiber cell genes in c-Maf null mice was analyzed by immunohistochemical and RT-PCR methods. In addition, the effect of c-Maf on fiber cell gene promoter fragments was examined in co-transfection experiments. RESULTS Examination of protein expression in c-Maf homozygous mutant mice revealed undetectable levels of CP49, CP115… CONTINUE READING

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