Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice

@inproceedings{Dyachenko2013AnalysisON,
  title={Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice},
  author={Igor A. Dyachenko and Arkadii N. Murashev and Tatyana V. Andreeva and V. I. Tsetlin and Yuri N Utkin},
  booktitle={Journal of venom research},
  year={2013}
}
Phospholipases A2 are represented in snake venoms by several types and possess diverse biological activities including neurotoxicity. Previously, we isolated and characterized two neurotoxic phospholipases A2 (HDP-1 and HDP-2) from the venom of Nikolski's viper (Vipera nikolskii), which were heterodimers composed of two non-covalently bound subunits. Each heterodimer consisted of an enzymatically active basic subunit and an inactive acidic subunit. In this work, we studied the in vivo… CONTINUE READING