Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice.

  title={Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice.},
  author={Andr{\'e}s Vazquez-Torres and T{\^a}nia M. Stevanin and Jessica Jones-Carson and Margaret E. Castor and Robert C Read and Ferric C Fang},
  journal={Methods in enzymology},
Nitric oxide (NO*) is a critical component of mammalian host defense that is produced in macrophages and other cells comprising the innate immune system. Isolated mammalian macrophages have been utilized to measure the kinetics of NO production and to demonstrate NO-related antimicrobial actions. Some microorganisms possess enzymes to detoxify nitrogen oxides, and mutant strains lacking these enzymes can be used to demonstrate the importance of these mechanisms for intracellular bacterial… CONTINUE READING

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