Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals.

@article{Li2009AnalysisON,
  title={Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals.},
  author={Yuxing Li and Krisha Svehla and Mark K. Louder and Diane L Wycuff and Sanjay Kumar Phogat and Min Tang and Stephen A Migueles and Xue-ling Wu and Adhuna Phogat and George M. Shaw and Mark Connors and James A Hoxie and John R. Mascola and Richard T. Wyatt},
  journal={Journal of virology},
  year={2009},
  volume={83 2},
  pages={1045-59}
}
During human immunodeficiency virus type 1 (HIV-1) infection, patients develop various levels of neutralizing antibody (NAb) responses. In some cases, patient sera can potently neutralize diverse strains of HIV-1, but the antibody specificities that mediate this broad neutralization are not known, and their elucidation remains a formidable challenge. Due to variable and nonneutralizing determinants on the exterior envelope glycoprotein (Env), nonnative Env protein released from cells, and the… CONTINUE READING

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