Analysis of neural crest–derived clones reveals novel aspects of facial development

  title={Analysis of neural crest–derived clones reveals novel aspects of facial development},
  author={Mark{\'e}ta Kauck{\'a} and Evgeny Ivashkin and Daniel Gyllborg and Tom{\'a}s Zikmund and Marketa Tesarova and Jozef Kaiser and Meng Xie and Julian Petersen and Vassilis Pachnis and Silvia K Nicolis and Tian Y Yu and Paul T Sharpe and Ernest Arenas and Hjalmar Brismar and Hans Blom and Hans Clevers and Ueli Suter and Andrei S Chagin and Kaj Fried and Andreas Hellander and Igor Adameyko},
  booktitle={Science Advances},
Cranial neural crest cells populate the future facial region and produce ectomesenchyme-derived tissues, such as cartilage, bone, dermis, smooth muscle, adipocytes, and many others. However, the contribution of individual neural crest cells to certain facial locations and the general spatial clonal organization of the ectomesenchyme have not been determined. We investigated how neural crest cells give rise to clonally organized ectomesenchyme and how this early ectomesenchyme behaves during the… CONTINUE READING
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