Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.

@article{Fanger1997AnalysisOM,
  title={Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.},
  author={Gary R Fanger and Richard R. Vaillancourt and Lynn E. Heasley and Jean Pierre Montmayeur and Gary Leon Johnson and Robert A. Maue},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 1},
  pages={89-99}
}
The mechanisms governing neuronal differentiation, including the signals underlying the induction of voltage-dependent sodium (Na+) channel expression by neurotrophic factors, which occurs independent of Ras activity, are not well understood. Therefore, Na+ channel induction was analyzed in sublines of PC12 cells stably expressing platelet-derived growth factor (PDGF) beta receptors with mutations that eliminate activation of specific signalling molecules. Mutations eliminating activation of… CONTINUE READING

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