Analysis of multidrug-resistance (MDR-1) glycoprotein and CD56 expression to separate monoclonal gammopathy from multiple myeloma.

@article{Sonneveld1993AnalysisOM,
  title={Analysis of multidrug-resistance (MDR-1) glycoprotein and CD56 expression to separate monoclonal gammopathy from multiple myeloma.},
  author={P. Sonneveld and Brian G. M. Durie and Henk M. Lokhorst and Yvette M Frutiger and Martijn Schoester and Elena Vela},
  journal={British journal of haematology},
  year={1993},
  volume={83 1},
  pages={63-7}
}
Monoclonal gammopathy of undetermined significance (MGUS) is different from multiple myeloma (MM) by a low proliferation and by its indolent clinical course. In this study, two biological parameters were investigated which mark the transition from MGUS to MM, i.e. expression of the P-170 glycoprotein associated with the multidrug resistance phenotype (MDR-1) and expression of the natural killer cell antigen. CD56. Strong MDR-1 expression was found in plasma cells of 32/38 untreated MGUS as… CONTINUE READING