Analysis of mtDNA copy number and composition of single mitochondrial particles using flow cytometry and PCR.

@article{Cavelier2000AnalysisOM,
  title={Analysis of mtDNA copy number and composition of single mitochondrial particles using flow cytometry and PCR.},
  author={Lucia Cavelier and Anders Johannisson and Ulf Gyllensten},
  journal={Experimental cell research},
  year={2000},
  volume={259 1},
  pages={
          79-85
        }
}
Mitochondrial DNA (mtDNA) is a multicopy, maternally inherited, genome. Individuals frequently carry a mixture of genetically distinct mtDNA molecules whose proportions may vary between sexual generations or among tissues from the same individual. Analyses of the genetic composition of mitochondria have previously relied on electron microscopy and have not permitted the genotype of single mitochondria to be determined. We have developed flow cytometry techniques to isolate single mitochondrial… CONTINUE READING

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