Analysis of mother-to-infant transmission of hepatitis C virus: quasispecies nature and buoyant densities of maternal virus populations.

@article{Kudo1997AnalysisOM,
  title={Analysis of mother-to-infant transmission of hepatitis C virus: quasispecies nature and buoyant densities of maternal virus populations.},
  author={Takahiro Kudo and Yoshio Yanase and Masaru Ohshiro and Mitsunari Yamamoto and Makoto Morita and Mari Shibata and Tsuneo Morishima},
  journal={Journal of medical virology},
  year={1997},
  volume={51 3},
  pages={225-30}
}
Mother-to-infant transmission of hepatitis C virus (HCV) was analyzed by sequencing of viral RNA and semiquantitative polymerase chain reaction following ultracentrifugation of maternal sera. In two mother-infant pairs, the hypervariable region 1 (HVR1) and carboxyl terminus of envelope 1 (E1) were sequenced. Both viral sequences in the infants were less diverse than those of their mothers. Although the E1 sequences were almost identical in each mother-infant pair, the HVR1 sequences of the… CONTINUE READING