Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.

@article{Excoffier1992AnalysisOM,
  title={Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.},
  author={Laurent Excoffier and Peter E. Smouse and Joseph M. Quattro},
  journal={Genetics},
  year={1992},
  volume={131 2},
  pages={
          479-91
        }
}
We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-distances among all pairs of haplotypes. This analysis of molecular variance (AMOVA) produces estimates of variance components and F-statistic analogs, designated here as phi-statistics, reflecting the correlation of haplotypic diversity at different levels of hierarchical… CONTINUE READING
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