Analysis of molecular inversion probe performance for allele copy number determination

@article{Wang2007AnalysisOM,
  title={Analysis of molecular inversion probe performance for allele copy number determination},
  author={Yuker Wang and Martin Moorhead and George Karlin-Neumann and Nicholas J. Wang and James S Ireland and Steven H Lin and Chunnuan Chen and Laura Heiser and Koei Chin and Laura Esserman and Joe W. Gray and Paul T. Spellman and Malek Faham},
  journal={Genome Biology},
  year={2007},
  volume={8},
  pages={R246 - R246}
}
We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 μg) by more than 25-fold (to 75 ng total genomic DNA), higher overall precision resulting in one order of magnitude lower false positive rate, and greater dynamic range with accurate absolute copy number up to 60 copies. 

From This Paper

Topics from this paper.
36 Citations
15 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 15 references

Similar Papers

Loading similar papers…