Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology.

@article{Bhattacharyya2010AnalysisOM,
  title={Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology.},
  author={Tanmoy Bhattacharyya and Jessica Rose Brooks and Matthew Ming Chong Yeo and Hern{\'a}n Jos{\'e} Carrasco and Michael David Lewis and Martin Stephen Llewellyn and Michael Alexander Miles},
  journal={International journal for parasitology},
  year={2010},
  volume={40 8},
  pages={
          921-8
        }
}
Chagas disease, marked by life-long chronic infection with Trypanosoma cruzi, remains a major parasitic disease in Latin America. Genetically heterogeneous, T. cruzi is divided into six discrete typing units (DTUs), most recently grouped as TcI-VI. The trypomastigote small surface antigen (TSSA) of T. cruzi has been described as the only known serological marker to identify infection by TcII-VI, as distinct from TcI. Here, by comparative analysis of a cohort of 25 reference strains representing… CONTINUE READING
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