Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale

  title={Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale},
  author={Steven Schmitt and Manuel Montalb{\'a}n-L{\'o}pez and David Peterhoff and Jingjing Deng and Ralf Wagner and Martin Held and Oscar P. Kuipers and Sven Panke},
  journal={Nature Chemical Biology},
The rise of antibiotic resistance demands the acceleration of molecular diversification strategies to inspire new chemical entities for antibiotic medicines. We report here on the large-scale engineering of ribosomally synthesized and post-translationally modified antimicrobial peptides carrying the ring-forming amino acid lanthionine. New-to-nature variants featuring distinct properties were obtained by combinatorial shuffling of peptide modules derived from 12 natural antimicrobial… 

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