Analysis of mitochondrial 12S rRNA and tRNASer(UCN) genes in patients with nonsyndromic sensorineural hearing loss from various regions of Russia

@article{Dzhemilova2009AnalysisOM,
  title={Analysis of mitochondrial 12S rRNA and tRNASer(UCN) genes in patients with nonsyndromic sensorineural hearing loss from various regions of Russia},
  author={L. U. Dzhemilova and Olga L Posukh and A. M. Tazetdinov and Nikolay A Barashkov and S. A. Zhuravskii and S. N. Ponidelko and Tatiana Markova and Vera N Tadinova and Sardana Fedorova and Nadezda Romanovna Maksimova and E. K. Khusnutdinova},
  journal={Russian Journal of Genetics},
  year={2009},
  volume={45},
  pages={861-869}
}
Mitochondrial DNA (mtDNA) mutations play an important role in etiology of hereditary hearing loss. In various regions of the world, patients suffer from nonsyndromic sensorineural hearing loss initiated by aminoglycoside antibiotics. Mutations that had been shown as pathogenetically important for hearing function disturbance were identified in mitochondrial 12S rRNA and tRNASer(UCN) genes while pathogenic role of several mtDNA sequences requires additional studies. Here we examined various… CONTINUE READING

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