• Corpus ID: 6780850

Analysis of mismatch distributions Introduction

@inproceedings{Holsinger2008AnalysisOM,
  title={Analysis of mismatch distributions Introduction},
  author={Kent E. Holsinger},
  year={2008}
}
Remember when we were talking about Tajima’s D? I pointed out that θ̂π, the estimate of 4Neμ derived from nucleotide sequence diversity is less sensitive to demographic changes than θ̂k, the estimate of 4Neμ derived from the number of segregating sites in the sample. I went on to argue that in a rapidly expanding population, mutation will not have “built up” the level of nucleotide diversity we’d expect based on the number of segregating sites, so that D̂ = θπ − θk will be negative. In a… 

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This article shows how to infer past demographic parameters by explicitly taking into account a finite-sites model with heterogeneity of mutation rates, and proposes an alternative way to derive confidence intervals around the estimated parameters, based on a bootstrap approach.
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This genetic evidence denies any version of the multiregional model of modern human origins and implies instead that the authors' ancestors were effectively a separate species for most of the Pleistocene.