Analysis of minocycline by high-performance liquid chromatography in tissue and serum.

@article{Wrightson1998AnalysisOM,
  title={Analysis of minocycline by high-performance liquid chromatography in tissue and serum.},
  author={W. Wrightson and S. Myers and S. Galandiuk},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={1998},
  volume={706 2},
  pages={
          358-61
        }
}
A sensitive and rapid reversed-phase high-performance liquid chromatography assay can be used to accurately determine serum and tissue minocycline concentrations. Minocycline is a broad spectrum tetracycline derivative with many applications. Tissue and serum samples were obtained from guinea pigs that had received either topical or intravenous minocycline. Samples were extracted using a Sep-Pak C18 cartridge and were injected into a microBondapak C18 column with an isocratic methanol mobile… Expand
Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat.
  • M. Čolović, S. Caccia
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