Analysis of minimal human immunodeficiency virus type 1 gag coding sequences capable of virus-like particle assembly and release.

@article{Wang1998AnalysisOM,
  title={Analysis of minimal human immunodeficiency virus type 1 gag coding sequences capable of virus-like particle assembly and release.},
  author={C T Wang and Hon Yee Lai and Joachim J. Li},
  journal={Journal of virology},
  year={1998},
  volume={72 10},
  pages={7950-9}
}
We have constructed a series of human immunodeficiency virus (HIV) gag mutants by progressive truncation of the gag coding sequence from the C terminus and have combined these mutants with an assembly-competent matrix domain deletion mutation (DeltaMA). By using several methods, the particle-producing capabilities of each mutant were examined. Our analysis indicated that truncated Gag precursors lacking most of C-terminal gag gene products assembled and were released from 293T cells… CONTINUE READING

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