Analysis of microglial gene expression: identifying targets for CNS neurodegenerative and autoimmune disease.

@article{Carson2004AnalysisOM,
  title={Analysis of microglial gene expression: identifying targets for CNS neurodegenerative and autoimmune disease.},
  author={Monica J. Carson and J Cameron Thrash and David D. Lo},
  journal={American journal of pharmacogenomics : genomics-related research in drug development and clinical practice},
  year={2004},
  volume={4 5},
  pages={321-30}
}
Microglia are the tissue macrophage of the central nervous system (CNS) and their activation is among the earliest signs of CNS dysfunction and disease. Because microglia express many macrophage markers, they are presumed to act primarily as effectors of CNS inflammation and destruction. While such responses are beneficial to the extent that they destroy CNS pathogens, these responses do have the potential to have neurotoxic outcomes. Consequently, therapies for many CNS neurodegenerative and… CONTINUE READING

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