Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model.

@article{Chen2009AnalysisOM,
  title={Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model.},
  author={J K Chen and Tumul Gupta and Jonah A. Barasz and Zhana Kalajzic and W-C Yeh and Hicham M Drissi and Arthur R Hand and Sunil Wadhwa},
  journal={Archives of oral biology},
  year={2009},
  volume={54 12},
  pages={1091-8}
}
OBJECTIVE Little is known about the natural progression of the disease process of temporomandibular joint (TMJ) osteoarthritis (OA), which affects approximately 1% of the US population. The goal of this study was to examine the early microarchitectural and molecular changes in the condylar cartilage and subchondral bone in biglycan/fibromodulin (Bgn/Fmod) double-deficient mice, which develop TMJ-OA at 6 months. METHODS TMJs from 3-month-old (n=44) and 9-month-old (n=52) wild-type (WT n=46… CONTINUE READING
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Deficiency in Nacetylgalactosamine-6-sulfate sulfatase results in collagen perturbations in cartilage of Morquio syndrome A patients

  • RA Bank, JE Groener, JJ van Gemund, PD Maaswinkel, KA Hoeben, HA Schut
  • Mol Genet Metab
  • 2009
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