Analysis of microRNA-induced silencing complex-involved microRNA-target recognition by single-molecule fluorescence resonance energy transfer.

@article{Li2012AnalysisOM,
  title={Analysis of microRNA-induced silencing complex-involved microRNA-target recognition by single-molecule fluorescence resonance energy transfer.},
  author={Ying Li and Chun-Yang Zhang},
  journal={Analytical chemistry},
  year={2012},
  volume={84 11},
  pages={5097-102}
}
MicroRNAs (miRNAs) are important regulators of gene expression that control almost every physiological and pathological process. Although the complementarity between the seed region of a miRNA and its target mRNA is usually deemed as the key determinant in the miRNA-target recognition in animals, the mechanism of their recognition still remains enigmatic as… CONTINUE READING