Analysis of miRNA and mRNA Expression Profiles Highlights Alterations in Ionizing Radiation Response of Human Lymphocytes under Modeled Microgravity

@inproceedings{Girardi2012AnalysisOM,
  title={Analysis of miRNA and mRNA Expression Profiles Highlights Alterations in Ionizing Radiation Response of Human Lymphocytes under Modeled Microgravity},
  author={Cristina Girardi and Cristiano De Pitta and Silvia Casara and Gabriele Sales and Gerolamo Lanfranchi and Lucia Celotti and Maddalena Mognato},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR pathway can originate from alteration in the functionality of the microRNA-mediated gene regulation, being microRNAs (miRNAs) small noncoding RNA that act as post-transcriptional regulators of gene expression. In this study we gained insight into the role of miRNAs in the regulation of DDR to IR under… CONTINUE READING
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