Analysis of metoprolol enantiomers in human serum by liquid chromatography on a cellulose-based chiral stationary phase.

@article{Straka1990AnalysisOM,
  title={Analysis of metoprolol enantiomers in human serum by liquid chromatography on a cellulose-based chiral stationary phase.},
  author={Robert J. Straka and Kelly A. Johnson and Peter S. Marshall and Rory P. Remmel},
  journal={Journal of chromatography},
  year={1990},
  volume={530 1},
  pages={83-93}
}
Metoprolol is a lipophilic, cardioselective beta-adrenergic blocking agent commercially available as a racemic compound. A normal phase high-performance liquid chromatographic method was developed to directly determine individual enantiomeric concentrations of metoprolol in human serum. Separation of the enantiomers was accomplished by a cellulose-tris(3,5-dimethylphenylcarbamate) chiral stationary phase. Metoprolol enantiomers were detected by means of fluorescence with excitation and emission… CONTINUE READING