Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.

@article{Doerge2000AnalysisOM,
  title={Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.},
  author={Daniel R. Doerge and Charles M Fogle and Merle G. Paule and Michael McCullagh and Sibinka Bajic},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2000},
  volume={14 8},
  pages={619-23}
}
Methylphenidate (MP, Ritalin) is a psychotropic drug widely prescribed to children for treating the symptoms of attention deficit disorder with and without hyperactivity. Because little information exists about the effects of chronic MP administration on cognitive function in children, measures of behavior changes in non-human primates are important surrogates. An essential component of such studies is the determination of MP plasma levels under chronic and acute dosing conditions. An… CONTINUE READING