Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data.

@article{Young2001AnalysisOM,
  title={Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data.},
  author={John Fariselli Young and Walter D. Wosilait and R H Luecke},
  journal={Journal of toxicology and environmental health. Part A},
  year={2001},
  volume={63 1},
  pages={19-52}
}
Physiologically based pharmacokinetic (PBPK) models are excellent tools to aid in the extrapolation of animal data to humans. When the fate of the chemical is the same among species being compared, animal data can appropriately be considered as a model for human exposure. For methylmercury exposure, sufficient data exist to allow comparison of numerous mammalian species to humans. PBPK model validation entails obtaining blood and tissue concentrations of the parent chemical and metabolite(s) at… CONTINUE READING