Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer

@article{Wang2005AnalysisOM,
  title={Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer},
  author={Wei Wang and Gudrun Huper and Yueqi Guo and Susan K. Murphy and John P. Olson and Jeffrey R. Marks},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2705-2714}
}
Treatment of the breast cancer cell line, MDAMB468 with the DNA methylation inhibitor, 5-azacytidine (5-AzaC) results in growth arrest, whereas the growth of the normal breast epithelial line DU99 (telomerase immortalized) is relatively unaffected. Comparing gene expression profiles of these two lines after 5-AzaC treatment, we identified 36 genes that had relatively low basal levels in MDAMB468 cells compared to the DU99 line and were induced in the cancer cell line but not in the normal… CONTINUE READING
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