Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.

@article{Oleary2005AnalysisOM,
  title={Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.},
  author={Valerie B O'leary and James L. Mills and Faith J Pangilinan and Peadar N. Kirke and Christopher Cox and Mary R Conley and Andrea Weiler and Kun Peng and Barry Shane and John M. Scott and Anne Parle-McDermott and Anne M. Molloy and Lawrence C. Brody},
  journal={Molecular genetics and metabolism},
  year={2005},
  volume={85 3},
  pages={220-7}
}
Methionine synthase reductase (MTRR) regenerates methylated cobalamin levels from the oxidised cob(II)alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase (MTR). MTR is an essential enzyme catalyzing the conversion of homocysteine to methionine. Single nucleotide polymorphisms (SNPs) within the MTRR gene may potentially compromise MTR activity leading to elevated homocysteine levels, a known risk factor for neural tube defects (NTDs). We… CONTINUE READING