Analysis of metagene portraits reveals distinct transitions during kidney organogenesis.

  title={Analysis of metagene portraits reveals distinct transitions during kidney organogenesis.},
  author={Igor F. Tsigelny and Valentina L. Kouznetsova and Derina E Sweeney and Wei Wu and Kevin T Bush and Sanjay K. Nigam},
  journal={Science signaling},
  volume={1 49},
Organogenesis is a multistage process, but it has been difficult, by conventional analysis, to separate stages and identify points of transition in developmentally complex organs or define genetic pathways that regulate pattern formation. We performed a detailed time-series examination of global gene expression during kidney development and then represented the resulting data as self-organizing maps (SOMs), which reduced more than 30,000 genes to 650 metagenes. Further clustering of these maps… CONTINUE READING
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