Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry.

@article{Jrgensen2012AnalysisOM,
  title={Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry.},
  author={Anne J\orgensen and John Nielsen and Martin Blomberg Jensen and Niels Gr{\ae}m and Ewa Rajpert-De Meyts},
  journal={Molecular human reproduction},
  year={2012},
  volume={18 11},
  pages={523-34}
}
The mitosis-meiosis switch is a key event in the differentiation of germ cells. In humans, meiosis is initiated in fetal ovaries, whereas in testes meiotic entry is inhibited until puberty. The purpose of this study was to examine the expression pattern of meiosis regulators in human gonads and to investigate a possible role of DMRT1 in the regulation of meiotic entry. The expression pattern of DMRT1, STRA8, SCP3, DMC1, NANOS3, CYP26B1 and NANOS2 was investigated by RT-PCR and… CONTINUE READING
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