Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.

@article{Zhou2011AnalysisOM,
  title={Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.},
  author={Jing Zhou and Constance E. Brinckerhoff and Susan M. Lubert and Kui Yang and Jasmine Saini and Jeffrey Hooke and Richard J. Mural and Craig Shriver and S. B. Somiari},
  journal={Cancer investigation},
  year={2011},
  volume={29 9},
  pages={599-607}
}
A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared… CONTINUE READING