Analysis of mammary specific gene locus regulation in differentiated cells derived by somatic cell fusion.

@article{Robinson2009AnalysisOM,
  title={Analysis of mammary specific gene locus regulation in differentiated cells derived by somatic cell fusion.},
  author={Claire Robinson and Andreas F. Kolb},
  journal={Experimental cell research},
  year={2009},
  volume={315 3},
  pages={508-22}
}
The transcriptional regulation of a gene is best analysed in the context of its normal chromatin surroundings. However, most somatic cells, in contrast to embryonic stem cells, are refractory to accurate modification by homologous recombination. We show here that it is possible to introduce precise genomic modifications in ES cells and to analyse the phenotypic consequences in differentiated cells by using a combination of gene targeting, site-specific recombination and somatic cell fusion. To… CONTINUE READING

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