Analysis of mammalian central nervous system gene expression and function using bacterial artificial chromosome-mediated transgenesis.

@article{Heintz2000AnalysisOM,
  title={Analysis of mammalian central nervous system gene expression and function using bacterial artificial chromosome-mediated transgenesis.},
  author={Nathaniel Heintz},
  journal={Human molecular genetics},
  year={2000},
  volume={9 6},
  pages={937-43}
}
The anatomical complexity of the mammalian central nervous system (CNS) presents special problems for the analysis of CNS gene expression and function. The most difficult challenge is presented by the simple fact that there are hundreds of functionally and morphologically defined cell types in the CNS. Given this complexity, the interpretation of CNS phenotypes is often problematic. The preparation of transgenic mice carrying marked bacterial artificial chromosomes (BACs) provides an important… CONTINUE READING
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