Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.

@article{Wadkins2007AnalysisOM,
  title={Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.},
  author={Randy M Wadkins and Janice L. Hyatt and Carol C. Edwards and Lyudmila G. Tsurkan and Matthew R. Redinbo and Craig E. Wheelock and Paul D Jones and Bruce D Hammock and Philip G. Potter},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 3},
  pages={713-23}
}
Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT-11) and capecitabine and the pyrethroid insecticides. Because of the role of CEs in the metabolism of many exogenous and endogenous ester-containing compounds, a number of studies have examined the inhibition of this class of enzymes. Trifluoromethylketone-containing (TFK) compounds have been identified as potent CE… CONTINUE READING

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