Analysis of macromolecular ethylene oxide adducts.

  title={Analysis of macromolecular ethylene oxide adducts.},
  author={Hermann Maximillian Bolt and Heidi Peter and U. F{\"o}st},
  journal={International archives of occupational and environmental health},
  volume={60 3},
Ethylene oxide is a carcinogenic compound which is also an ethylene metabolite. Ethylene oxide forms macromolecular adducts with proteins and nucleic acids. Targets in proteins are the amino acids cysteine, histidine and valine (if N-terminal, as in hemoglobin). The major DNA adduct is 7-(2-hydroxyethyl)-guanine. Methods for detection of this adduct include… CONTINUE READING