Analysis of loss of heterozygosity in lymphoma and leukaemia arising in F1 hybrid mice locates a common region of chromosome 4 loss.

@article{Meijne2001AnalysisOL,
  title={Analysis of loss of heterozygosity in lymphoma and leukaemia arising in F1 hybrid mice locates a common region of chromosome 4 loss.},
  author={Emmy Meijne and Rene Huiskamp and Jackie W Haines and John Moody and Rosemary Finnon and Jennifer Wilding and S Spanjer and Simon Bouffler and Alan Edwards and R. B. Cox and Andrew Silver},
  journal={Genes, chromosomes & cancer},
  year={2001},
  volume={31 4},
  pages={373-81}
}
Previous studies have identified five lymphoma-related tumour suppressor gene regions on murine chromosome 4. Using detailed allelotype analysis on a range of lympho-haematopoietic tumour types arising in F1 hybrid mice, we now show a consistent pattern of loss of heterozygosity (LOH) which identifies a common region of loss delineated by microsatellites D4Mit21 and D4Mit53 on proximal chromosome 4. This critical segment corresponds to the thymic lymphoma tumour suppressor region 5 (TLSR5… CONTINUE READING