Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response

@article{Wang2008AnalysisOL,
  title={Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response},
  author={Desheng Wang and Deya S. Darwish and Bernard G. Schreurs and Daniel L. Alkon},
  journal={Behavioural Pharmacology},
  year={2008},
  volume={19},
  pages={245-256}
}
Previous work demonstrated that protein kinase C (PKC) is implicated in learning and memory. This study investigated whether: (i) PKC activated by bryostatin-1 (Bryo) just before or just after sessions of classical conditioning was capable of enhancing classical conditioning of the rabbit nictitating membrane response; (ii) improved behavioral performance matched the time course of PKC activation induced by Bryo; and (iii) vitamin E (Vit E) enhanced the efficacy of Bryo. Paired rabbits received… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Effects of 4-aminopyridine on classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response
TLDR
4-Aminopyridine enhanced both classical conditioning and conditioning-specific reflex modification compared with a saline vehicle control, and these effects had several nonassociative components including an increase in the frequency of responding to both the conditioned and the unconditioned stimuli, suggesting a sensitizing effect of the drug. Expand
Bryostatin Enhancement of Memory in Hermissenda
TLDR
Overall, the data indicated that PKC activation occurred and calexcitin levels were raised during the acquisition phases of associative conditioning and memory initiation, and subsequently returned to baseline levels within 24 and 48 h, respectively. Expand
Sensory and associative effects of LSD in classical conditioning of rabbit (Oryctolagus cuniculus) nictitating membrane response
: Three experiments were conducted to determine the effects of LSD (30 nmol/kg) on the acquisition of the rabbit's classically conditioned nictitating membrane response. Experiment 1 revealed thatExpand
Sensory and associative effects of morphine and naloxone in classical conditioning of the rabbit nictitating membrane response
TLDR
The retardant effect of morphine on the acquisition of conditioned responses appears to be primarily due to an action on opioid receptors that produces a decrease in the sensory processing of the conditioned stimulus. Expand
Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning.
TLDR
Bryo-induced PKC activation produces those proteins necessary and sufficient for long-term memory on days in advance of the training events themselves, and the specific PKC antagonist Ro-32-0432 blocked much of this Bryi-induced protein synthesis as well as the Bryo- induced enhancement of the behavioral conditioning. Expand
Conditioning the unconditioned response: modification of the rabbit's (Oryctolagus cuniculus) unconditioned nictitating membrane response.
TLDR
Data indicate CRM is a reliable, associative effect that is more than a generalized CR and may not be explained by habituation, stimulus generalization, contextual conditioning, or bidirectional conditioning. Expand
US-US conditioning of the rabbit’s nictitating membrane response: Emergence of a conditioned response without alpha conditioning
Two experiments were conducted to examine whether classical conditioning of the rabbit’s nictitating membrane response (NMR) could be obtained when paraorbital electrical stimulation served as bothExpand
Dissociable effects of the 5-HT2 antagonist mianserin on associative learning and performance in the rabbit
TLDR
It is concluded that mianserin acts as an inverse agonist at the serotonin 5-HT(2) receptor to produce both a retardation of CR acquisition and an impairment of the UR. Expand
Classical conditioning increases membrane‐bound protein kinase C in rabbit cerebellum
TLDR
Results indicate PKC activation in lobule HVI may be important in acquisition of conditioned eyeblink responses and there was a statistically significant increase in [3H]PBt2 binding within the molecular layer of lobules HVI in rabbits given paired training relative to controls. Expand
Dual effects of bryostatin-1 on spatial memory and depression.
TLDR
Bryostatin-1, a protein kinase C substrate activator, at bilateral intracerebroventricular doses of 0.64 or 2 pmol/site, significantly enhanced learning and memory of rats in a spatial water maze task and support the hypothesis that memory processing and mood regulation share common neural mechanisms. Expand
...
1
2
3
4
5
...