Analysis of locus heterogeneity in Waardenburg syndrome types 1 and 2 using highly informative microsatellite markers.

@article{Reynolds1995AnalysisOL,
  title={Analysis of locus heterogeneity in Waardenburg syndrome types 1 and 2 using highly informative microsatellite markers.},
  author={Je ery S. Reynolds and Kathleen Shaver Arnos and Blanca Landa and Christy A Stevens and Bonnie Anne Salbert and Lesley Wright and B D Duke and W L Hunt and Mary L. Marazita and Lynn M. Ploughman},
  journal={Human heredity},
  year={1995},
  volume={45 5},
  pages={243-52}
}
We performed linkage and locus heterogeneity analyses of Waardenburg syndrome (WS) types 1 and 2 using 9 DNA markers from 2q35-q37, including two highly polymorphic microsatellites very closely linked to the PAX3 candidate gene. None of 5 WS type 2 (WS2) families showed linkage to the PAX3 candidate region. We localized the marker D2S102 to less than 1 cM… CONTINUE READING