Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families

@article{Pylks2008AnalysisOL,
  title={Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families},
  author={Katri Pylk{\"a}s and Hannele Erkko and Jenni Nikkil{\"a} and Szilvia S{\'o}lyom and Robert Winqvist},
  journal={BMC Cancer},
  year={2008},
  volume={8},
  pages={146 - 146}
}
BRCA1 and BRCA2 are the two most important genes associated with familial breast and ovarian cancer susceptibility. In addition, PALB2 has recently been identified as a breast cancer susceptibility gene in several populations. Here we have evaluated whether large genomic rearrangement in these genes could explain some of Finnish breast and/or ovarian cancer families. Altogether 61 index patients of Northern Finnish breast and/or ovarian cancer families were analyzed by Multiplex ligation… CONTINUE READING

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