Analysis of key cell-cycle checkpoint proteins in colorectal tumours.

  title={Analysis of key cell-cycle checkpoint proteins in colorectal tumours.},
  author={Judith McKay and Joy J. Douglas and Val G. Ross and Stephanie Curran and Joseph F. Loane and Fareeda Y. Ahmed and John Cassidy and Ping Liao and Graeme I. Murray},
  journal={The Journal of pathology},
  volume={196 4},
Aberrations in the components of cell-cycle checkpoints are a common feature of many tumours and several have been shown to have prognostic significance in colorectal cancer. In this study, seven components of cell-cycle control [cyclin D1, retinoblastoma (pRb), p21, p27, p16, p53, and proliferating cell nuclear antigen (PCNA)] were examined in a large series of well-characterized colorectal adenocarcinomas using immunohistochemistry to ascertain co-regulation and influence on survival. The… CONTINUE READING
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