Analysis of junctional diversity in the preferential V delta 1-J delta 1 rearrangement of fresh T-acute lymphoblastic leukemia cells by in vitro gene amplification and direct sequencing.

@article{Macintyre1989AnalysisOJ,
  title={Analysis of junctional diversity in the preferential V delta 1-J delta 1 rearrangement of fresh T-acute lymphoblastic leukemia cells by in vitro gene amplification and direct sequencing.},
  author={E A Macintyre and L. d'Auriol and Françoise Amesland and Pascale Loiseau and Z Chen and Laurence Boumsell and Francis Galibert and François Sigaux},
  journal={Blood},
  year={1989},
  volume={74 6},
  pages={2053-61}
}
To define the junctional diversity of T-cell antigen receptor delta gene rearrangements in fresh T-acute lymphoblastic cells and to correlate cell phenotype with the coding potential of rearrangements, we determined the junctional nucleotide sequences of 13 T-cell antigen receptor delta gene rearrangements involving the preferentially rearranged V (V delta 1) and J (J delta 1) segments using in vitro gene amplification and direct sequencing. We showed that, as in gamma delta+ cell lines… CONTINUE READING

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