Analysis of interleukin-1 beta-induced cell signaling activation in rat hippocampus following exposure to gamma irradiation. Protective effect of eicosapentaenoic acid.

@article{Lynch2003AnalysisOI,
  title={Analysis of interleukin-1 beta-induced cell signaling activation in rat hippocampus following exposure to gamma irradiation. Protective effect of eicosapentaenoic acid.},
  author={Aileen M Lynch and Michelle Moore and Sarah Craig and Peter E Lonergan and Darren S D Martin and Marina A. Lynch},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 51},
  pages={51075-84}
}
Among the many reported effects of irradiation in cells is activation of the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), which has been shown to result in apoptotic cell death. The trigger that leads to JNK activation has not been identified, although, in rat hippocampus at least, irradiation-induced apoptosis has been coupled with increased accumulation of reactive oxygen species (ROS). Significantly, irradiation-induced changes in hippocampus are abrogated by treatment of… CONTINUE READING

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